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Occitanus israelis showing preference for Shaker N: Isolation of the first toxin from the scorpion Buthus Kozminsky-Atias A, Somech E and Zilberberg Gomes A, Bhattacharjee P, Mishra R, BiswasĪK, Dasgupta SC and Giri B: Anticancer potential of animal venomsĪnd toxins. Southern African scorpion toxins: An overview. View Article : Google Scholar : PubMed/NCBIĭu Plessis LH, Elgar D and du Plessis JL: Parabutoporin, a cationic amphipathic peptide from scorpion venom: Tytgat J: Scorpion toxins specific for Na +-channels. View Article : Google Scholar : PubMed/NCBIĬycle-related gene expression in aging hematopoietic stem cells:Įnigma of their recovery. Marrow-derived stem cells and radiation response. In conclusion, the present study demonstrated that SVP‑B5 has growth factor‑like properties and may be used as a therapeutic modality in the recovery of severe myelosuppression, which is a common side effect of radiotherapy.
#Svp abstracts Activator#
Treatment of M‑NFS‑60 cells with SVP‑B5 upregulated the expression of interleukin 3 receptor and activated the Janus kinase‑2/signal transducer and activator of transcription 5 signaling pathway. In addition, SVP‑B5 effectively and persistently promoted hematopoietic recovery and expansion of hematopoietic cells after irradiation as demonstrated by cobblestone area forming cell and long‑term bone marrow culture assays. SVP‑B5 significantly promoted the proliferation of irradiated M‑NFS‑60 mouse‑derived myelocytic leukemia cells. In the present study, the SVP‑B5 polypeptide, which is one of the active components of SVPII, was purified using a two‑step chromatographic process. Previous studies have demonstrated the radioprotective efficacy of scorpion venom peptide, fraction II (SVPII) from the venom of Buthus martensii Karsch.
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